Twitter is so 2D, so why not move into the new world of 3D? Twitt3D does just that. You use the mouse to activate the window after entering your Twitter credentials (not oauth) and then utilize the mouse and arrows to fly around. The avatars and tweets then start flying in. I can see if you have thousands of people you follow this could be overwhelming.
After having some issue with Firefox throwing avatars all over, I finally clicked one and got the tweet itself. Some avatars were bigger (presuming more followers or posts) and others smaller. I couldn’t use this day to day, but an interesting graphing tool and use of Twitter.