TweetNewz (via (jeff)isageek today) is a whole lot of footprint on your desktop UI for starters. It brings together news feeds and allows you to perform feed management and then tweet and discuss those feeds. It runs as an Adobe Air application, so you get cross platform capability right away.
I was concerned with having to bring in OPML files or manually enter feeds, but it does sync with Google Reader, where I have everything already. The news ticker itself can be docked anywhere on any side of your screen.
Publishers can create their own branded news ticker. I did this before with Particls and had huge success in the amount of downloads where I had also pre-loaded tons of feeds.
I wished there was more help avaiable on the site itself as I had many questions to ask before loading it.