ComboTweet didn’t win the shiniest UI when first entering the site. After changing the settings to use the light background (amass a bunch of others we will talk about) it was decent.
So the first thing you need to do is log into the site with one of your many Twitter accounts. You can log in with OAuth, the old way, into their site to save search panels or create filtered panels. If you use their login to save panels your choices are OpenID, Google, AOL and Yahoo.
A filtered panel allows you to show tweets from one person from one of your other panels.
Other settings include tabbed browsing, inclusion of hashtags, URL shortening, autosaving of panels and refresh rates.
I tried the OAuth a few times and never got connected so I got slightly frustrated. There was a search ability also but I left that for later.