I really liked the looks of this for multi platform. I still run Twhirl for now personally, but this added some functions. Including webcam shots and file transfers up to 10MB
Send files to your friends, but just dragging any file on to Tweetr. Tweetr will automatically upload your file and when it is done will provide a short url to send to your friends.
Use the webcam feature to show off you latest toys, bruise, haircut.